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《美国科学杂志》《应用化学杂志》报道：最新研究再次证实转基因Bt玉米对哺乳动物睾丸 ...

2014-1-14 12:45| 发布者: 风在手| 查看: 7403| 评论: 0|原作者: 《转基因技术与人类安全》专家陈一文|来自: 新浪

摘要: 《美国科学杂志》、《应用化学杂志》对埃及科学家同一项转基因Bt玉米与对应非转基因玉米不同方面比较研究发表的三篇新论文证实：1） “实质不等同”，而不是“实质等同”；2）含转基因Bt玉米饲料对老鼠造成器官重量/ ...

《美国科学杂志》、《应用化学杂志》对埃及科学家同一项转基因Bt玉米与对应非转基因玉米不同方面比较研究发表的三篇新论文证实：1） “实质不等同”，而不是“实质等同”；2）含转基因Bt玉米饲料对老鼠造成器官重量/体重或血液生物化学变化，表明可能的毒性。3）喂含转基因Bt玉米饲料91天造成危害生育能力基础的睾丸精原细胞坏死（死亡）和脱屑（脱落）！

又一项老鼠喂养研究表明转基因Bt玉米对哺乳动物有毒性

Another rat feeding study shows GM Bt corn toxic to mammals

陈一文（cheniwan@cei.gov.cn）

《转基因技术与人类安全》研究专家、80年代前全国青联委员

《新浪网》“陈一文顾问博客”：http://blog.sina.com.cn/cheniwan

转载自《转基因观察》网站：http://www.gmwatch.org/index.php/news/archive/2014/15260

（ 2014-01-14）

Egyptian researchers found Bt corn was not substantially equivalent to non-GM parent and was toxic to rats, even after only 91 days of feeding.

埃及研究者发现转基因Bt玉米与非转基因玉米不等同，而且，转基因Bt玉米对老鼠有毒性，即便喂养仅仅91天之后。

These findings arose from three studies published in 2012 and 2013 on a type of GM insect resistant Bt corn developed using Monsanto's MON810 trait.

这些发现来自2012年与2013年发表的对使用孟山都MON810性状的抗虫Bt转基因玉米的三项研究论文。

One study[1] showed that the GM corn was not substantially equivalent to the non-GM parent.

头一个研究[1]表明转基因玉米与非转基因父母本实质不等同。

A second study[2] examined the effects on rats of a diet containing the GM maize. The study found that the GM corn diet caused increased or decreased organs/body weight or changes in blood biochemistry that indicated possible toxicity.

第二项研究[2]审查了含转基因玉米饲料对老鼠的影响。这些研究发现转基因玉米造成或减少器官的重量/体重或者造成血液生物化学变化，表明可能的毒性。

In the third study[3], histopathological examination was carried out on the rats fed the GM maize, and the results were compared with rats fed non-GM maize. The study found clear signs of organ pathology in the GM-fed group, especially in the liver, kidney, and small intestine. An examination of the testes revealed necrosis (death) and desquamation (shedding) of the spermatogonial cells that are the foundation of sperm cells and thus male fertility - and all this after only 91 days of feeding.

在第三项研究中[3]，对喂养转基因玉米老鼠进行了组织病理学检查，检查结果与喂养非转基因玉米的老鼠进行比较。该项研究在喂养转基因玉米组中发现了清楚的器官病理学症状，特别在肝、肾，与小肠。对睾丸的检查揭示发生坏死（死亡）和脱屑（脱落）的精原细胞，它们是精子细胞的基础并因而也是雄性生育能力的基础 – 而且所有这些发生在仅仅91天喂养之后。

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参考文献及其摘要：

[1] Abdo E.M. et al. Chemical Analysis of BT corn "Monsanto810:Ajeeb-YG" and its counterpart non-Bt corn "Ajeeb" IOSR Journal of Applied Chemistry (IOSR-JAC) e-ISSN:2278-5736. Vol 4 Issue 1 (Mar-April, 2013) pp55-60

[1] Abdo E.M. et al. ，转基因Bt玉米“孟山都810：Ajeeb-YG”及其对应非转基因玉米“Ajeeb”的化学分析，IOSR 应用化学杂志(IOSR-JAC) e-ISSN:2278-5736. 第4卷第1期（3月-4月，2013） pp55-60，

http://www.academia.edu/3341205/Chemical_Analysis_of_Bt_corn_Mon-810_Ajeeb-YG_and_its_counterpart_non-Bt_corn_Ajeeb_

第4卷第1期整期下载：http://iosrjournals.org/iosr-jac/full-issue/vol4-issue1.pdf

Abstract:

摘要：

Commercialization of biotech crops has started since 1996, where the cultivated area of these crops was increased from 1.7 million hectares in 1996 to 170.3 million hectares in 2012 according to the latest statistics in 2012. Bt corn "MON810: Ajeeb YG®" is one of these crops that express endotoxin from Bacillus thuringiensis (Bt) throughout the whole plant. This study was designed to assess the safety of Bt corn by comparing its compositional chemical analysis with its conventional counterpart "Ajeeb". Moisture content, crude fat, total saccharides, starch, & crude fiber were determined; sodium, potassium, magnesium, calcium and phosphorous content were measured, tannins & phytic acid were determined as anti-nutrients. Amino acids and fatty acids profiles were also evaluated. Results indicated the presence of significant differences between both of Bt corn and its counterpart.

生物技术作物商业化始于1996年，这种作物的种植面积1996年为170公顷，2012年增加到1.703亿公顷，依据2012年最新的统计数字。Bt玉米“MON810: Ajeeb YG®”是这样的作物中的一种，在整个作物表达苏云金杆菌(Bt) 的内毒素。该项研究设计来评估Bt玉米的安全性，通过与其传统对应“Ajeeb”比较其成分的化学分析。水分、粗脂肪、总糖类、淀粉，与粗纤维被确定；钠、钾、镁、钙和磷成分被测量；单宁和植酸测定抗营养因子作为抗营养物被确定。氨基酸与脂肪酸构成也进行了评价。结果显示Bt玉米及其对应非转基因玉米之间存在显著差别。

[2] Gab-Alla, A et al. Morphological and Biochemical Changes in Male Rats Fed on GM corn (Ajeeb YG) Journal of American Science 2012 8(9)

[2] Gab-Alla, A et al. 喂养转基因玉米（Ajeeb YG）的雄鼠中的形态与生物化学改变，美国科学杂志2012 8(9)

http://www.academia.edu/3138607/Morphological_and_Biochemical_Changes_in_Male_Rats_Fed_on_Genetically_Modified_Corn_Ajeeb_YG_

全文下载：http://www.jofamericanscience.org/journals/am-sci/am0809/152_11742am0809_1117_1123.pdf

Abstract:

摘要：

This study was designed to evaluate the safety of genetically modified (GM) corn (Ajeeb YG). Corn grains from Ajeeb YG or its control (Ajeeb) were incorporated into rodent diets at 30% concentrations administered to rats (n= 10/group) for 45 and 91 days. An additional negative control group of rats (n=10/group) was fed AIN93G diets. General conditions were observed daily, total body weights were recorded weekly. At the termination of the study periods, some visceral organs (heart, liver, kidneys, testes and spleen) and serum biochemistry were measured. The data showed several statistically significant differences in organs/body weight and serum biochemistry between the rats fed on GM and/or Non-GM corn and the rats fed on AIN93G diets. In general, GM corn sample caused several changes by increase or decrease organs/body weight or serum biochemistry values. This indicates potential adverse health/toxic effects of GM corn and further investigations still needed.

该项研究被涉及评估转基因玉米（Ajeeb YG）的安全性。来自Ajeeb YG或其对照（Ajeeb）的玉米粒以30%比例被加入到啮齿动物饲料喂养老鼠（n=10/组）45天与91天。此外，负对照组的老鼠（n=10/组）喂养AIN93G饲料。总的情况每天观察，总体重每周记录。研究期结束后，某些脏器（心、肝、肾脏、睾丸和脾）和血清生化进行测定。数据表明，喂养转基因和/或非转基因玉米的老鼠与AIN93G饲料的老鼠，在器官/体重与血清生化存在数项统计显著差别。总的来讲，转基因玉米样品造成数项改变，增加或减少器官/体重或血清生化指标。这表明转基因玉米造成潜在健康/毒性影响，有必要进行进一步研究。

[3] El-Shamei, ZS et al, Histopathological Changes in Some Organs of Males Rats Fed on GM corn (Ajeeb YG) Journal of American Science 2012 8(10)

[3] El-Shamei, ZS et al, 喂食转基因玉米（Ajeeb YG）雄鼠的某些器官中组织病理学变化，美国科学杂志2012 8(10)

http://www.academia.edu/3405345/Histopathological_Changes_in_Some_Organs_of_Male_Rats_Fed_on_Genetically_Modified_Corn_Ajeeb_YG_

全文下载：http://www.jofamericanscience.org/journals/am-sci/am0810/093_11743am0810_684_696.pdf

Abstract:

摘要：

Ajeeb YG is a genetically modified (GM) insect resistant corn produced by incorporated the MON 810 (Monsanto) borer resistance trait in the best corn germplasm Ajeeb. The safety of Ajeeb YG corn was assessed by comparison of toxicology response variables in rats consuming diets containing Ajeeb YG with those containing Ajeeb corn grains. Corn grains from Ajeeb YG or Ajeeb were incorporated into rodent diets at 30% concentrations administered to rats (n=10/group) for 91 days. An additional negative control group of rats (n=10/group) were fed AIN93G diets. Rats fed on GM corn showed histopathological changes. Liver displayed cytoplasmic vacuolation of centrolobular hepatocytes and fatty degeneration of hepatocytes. Kidneys showed congestion of renal blood vessels and cystic dilatation of renal tubules. Testes revealed necrosis and desquamation of spermatogoneal germ cells lining seminiferous tubules. Spleen showed slight lymphocytic depletion and splenic congestion. Small intestine showed hyperplasia, hyperactivation of mucous secretory glands and necrosis of intestinal villi were detected. Due to these observations, we suggest that the risk of GM crops cannot be ignored and deserves further investigations in order to identify possible long-term effects, if any, of GM food consumption that might help in the post market surveillance.

Ajeeb YG是一种抗虫转基因玉米，通过将MON810（孟山都）抗玉米螟性状转入最好的玉米种质Ajeeb。通过比较喂养含转基因Ajeeb YG玉米谷粒饲料与喂养含非转基因Ajeeb玉米谷粒饲料的老鼠中毒理学响应变量进行评价。转基因Ajeeb YG玉米或者非转基因Ajeeb谷粒以30%比例加入脊椎动物饲料，喂给老鼠（n=10/组）91天。对另外一个负对照组老鼠（n=10/组）喂养AIN93G饲料。喂养转基因玉米的老鼠显示组织病理学变化。肝脏显示小叶中心部分的肝细胞的肝细胞质空泡形成和肾小管的囊状扩张。肾脏显示肾血管的阻塞和肾小管的囊状扩张。睾丸显示产生精子的生殖细胞衬里细精管坏死和脱落。脾显示轻微的淋巴细胞耗竭和脾充血。小肠显示增生，粘液分泌腺过度活性，探测到肠道绒毛的坏死。由于观察到的这些现象，我们认为转基因作物的风险不可以忽略，而且有必要进行进一步研究以便识别食用转基因食品可能的长期影响，如果有任何这样影响的话，这样有助于对转基因食品进入市场后的后期监督。